Langbakk, Bodil; Wærhaug, Kristine; Kuklin, Vladimir N.; Kirov, Mikhail Y.; Sovershaev, Mikhail; Ingebretsen, Ole C.; Ytrehus, Kirsti; Bjertnæs, Lars J. (Journal article; Tidsskriftartikkel; Peer reviewed, 2008-08-15)
Introduction: Acute lung injury often complicates severe sepsis.
In Gram-negative sepsis, bacterial endotoxin activates both
coagulation and inflammation. Enhanced lung vascular
pressures and permeability, increased extravascular lung water
content and deteriorated gas exchange characterize ovine
endotoxin-induced lung injury, a frequently used model of acute
lung injury. Recombinant human ...